Rural entrepreneurship has been seen by the central government of China as a key means to rural vitalization. However, research focus on the long-term developmental status of rural entrepreneurship at local scale has been limited. According to industry types of differentiation, this research describes rural enterprises registered in the administrative area of Mianyang, southwest China, from 2011 to 2020. The spatial-temporal distribution rule of rural entrepreneurship is explored via a quantitative approach focused on spatial analysis and correlation analysis, as well as the application of geocoding on web data. How contexts such as the natural base, socio-economic condition, and institutional arrangements impact this distribution are empirically explored and discussed. The paper adds spatial-temporal insights into the role of the context of rural entrepreneurship. In particular, the paper highlights that rural entrepreneurship is a process potentially best explored at the regional scale and that physical condition and institutional support play central roles in rural entrepreneurship in southwest China.