Stem cell lineage in body layer specialization and vascular patterning of rice root and leaf Science Bulletin 61, 847 (2016); Study on the determinants of suckling mice neurovirulence of dengue 2 virus Science in China Series C-Life Sciences 46, 95 (2003); Article A systematic study of the determinants of protein abundance memory in cell lineage

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Quiescent cell ages by declining with age in both the survivability and regenerative activity. While most cellular quiescence/ageing research have been focused on the survivability and from the population level, how does the regenerative activity change with the quiescence time (i.e., chronological age) has rarely been addressed quantitatively. In this work, we systematically measured both features in ageing quiescent fission yeast cells at single cell level. We found that the regenerative activity declines linearly before survivability decline and the cellular chronological ageing speed is predetermined by the initial niche condition. Moreover, this linear ageing behavior is robust under various niche conditions and follows a common ageing trajectory in terms of gene expression. Furthermore, initial calorie restriction was found can improve not only the survivability but also the later regenerative activity. Our results reveal the depth diversity and ageing plasticity of quiescent cells.