Synthesize target molecules, multicomponent reaction of 4-(4-aminophenyl) morpholin-3-one with various pyrazole aldehydes and ethylacetoacetate or methylacetoacetate afforded various 1,4-dihydropyridines derivatives. The newly synthesized compounds were characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis.

The literature review reveal that [1,4]-oxazine derivatives represent one of the most active classes of compounds possessing wide spectrum of biodynamic activities and use as potent therapeutic agents. In the present work, a series of Schiff base of 2-(2,3-dihydro-2-oxonaphtho[2,1-b][1,4]oxazin-1-yl)acetohydrazide, 5a-5j has been synthesized using 1-aminonaphthalen-2-ol. Various aromatic aldehyde were react with carbohydrazide 4 in the presence of acid to produce the 2-oxonaphtho[2,1-b][1,4]oxazin Schiff base derivatives with good yields. All synthesized compounds were characterized by IR, NMR and Mass spectrometry analysis.

The literature review reveal that [1,4]-oxazine derivatives represent one of the most active classes of compounds possessing wide spectrum of biodynamic activities and use as potent therapeutic agents. In the present work, a series of Schiff base of 2-(2,3-dihydro-2-oxonaphtho[2,1-b][1,4]oxazin-1-yl)acetohydrazide, 5a-5j has been synthesized using 1-aminonaphthalen-2-ol. Various aromatic aldehyde were react with carbohydrazide 4 in the presence of acid to produce the 2-oxonaphtho[2,1-b][1,4]oxazin Schiff base derivatives with good yields. All synthesized compounds were characterized by IR, NMR and Mass spectrometry analysis.

Synthesize target molecules, multicomponent reaction of 4-(4-aminophenyl) morpholin-3-one with various pyrazole aldehydes and ethylacetoacetate or methylacetoacetate afforded various 1,4-dihydropyridines derivatives. The newly synthesized compounds were characterized by IR, Mass, 1H NMR, 13C NMR spectroscopy and elemental analysis.