OBJECTIVE-The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes.STUDY DESIGN-Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities.RESULTS-Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG-from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint.CONCLUSION-Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications. Keywords adverse outcomes; gestation; lipidsA number of diseases affecting the cardiovascular system emerge during pregnancy. Gestational diabetes mellitus is a risk factor for the development of type 2 diabetes and gestational hypertension is associated with an elevated risk for developing subsequent systemic hypertension. 1-3 Gestational diabetes and hypertension can contribute to maternal and fetal risk of developing peri-and postpartum complications. 4,5 Reprints: Victor Novack, MD, PhD,

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Therapy with statins may be associated with a reduced risk of infection-related mortality. This protective effect is independent of all known comorbidities and dissipates when the medication is discontinued. If this finding is supported by prospective controlled trials, statins may play an important role in the primary prevention of infection-related mortality.