The aim of this study is to examine the relationship between high-performance work systems (HPWS), sustainable development, and knowledge sharing in small and medium enterprises (SMEs) in Jordan. In this study it is hypothesized that the ability, motivation, and opportunity (AMO) improving the human resource (HR) practices of SMEs leads to better organizational performance of their employees through the role of knowledge sharing moderation. The results of this study confirm the hypothesis of the causal relationship between AMO practice with sustainable development, and the hypothesis of AMO practice with sustainable development are influenced by knowledge sharing. This study has implications for practice and theory, also can help project managers from these organizations to plan better human resource management (HRM) practices to promote sustainable development through innovation and creative performance of their employees. Therefore, this is one of the first studies to discuss the HRM productivity in AMO practice, and its important role in knowledge sharing.