This paper proposes to use a white-box approach to identify the parameters of an electronic DC-DC buck converter. It discretizes the differential equations governing the dynamic of such system, which are used to identify the parameters of the electronic components of the converter and the control loop. The proposed method is used to calculate the system parameters from the open loop and closed loop outputs, that is, the steady state and transient state stages of the output signals. The approach is validated by comparing simulation results from PSIM models of the converter with experimental data obtained from a commercial non-synchronous buck converter. Both simulation and experimental results show the feasibility and accuracy of the proposed approach in identifying the parameters of the converter, thus being feasible to obtain a full representation of such power converter. I.
McDonald's is one of the most successful fast food companies around the world. It has approximately 32,000 outlets located in 119 countries. Being a global and modern fast food company, McDonald's has a clear vision, "to be the world's best quick service restaurant experience". This paper presents the contributing factors which drive McDonald's success being a global and modern fast food company. McDonald's top management believes that job satisfaction and motivation are the contributing factors to the success of McDonald's. McDonald's has won many awards over the years for its employees' engagement programs.
2006). The tumors disappeared, presumably because they were attacked by the improved immune system. Seeing that the results were positive, his approach caught on. In recent years, the most prominent immunomodulatory strategy has been using chimeric antigen receptor T-cell (CAR-T) immunotherapy, which has had striking complete remission (CR) rates as high as 90% in acute lymphoblastic leukemia (ALL).Unfortunately, CAR-T cells have some significant limitations. One of the major hardships with the generation of an autologous CAR-T cell product is that it is derived from each patient individually, making it too difficult to scale for widespread clinical use. In fact, it takes a minimum of two to three weeks to manufacture CAR-T cells (Hay and Turtle, 2017). Therefore, for a patient in critical condition with a rapidly advancing disease, treatment with CAR-T cells would be impractical. Additionally, it is difficult to collect the required quantity of lymphocytes from patients to generate CAR-T cells. And, in the case of allogenic T cells, which are transported from a donor, they can cause graft-versus-host disease (GVHD) (Liu et al., 2017).The newly discovered CAR NK cells are perhaps more promising than the CAR-T cells. NK cells are cytotoxic, or cell-killing, and kill their targets in a non-specific manner. This means NK cells don't have to recognize a specific antigen on viral-infected cells or cancer cells (Farag and Caligiuri, 2006: Locatelli et al., 2014). Consequently, this enhances their immunosurveillance. The NK cells decide whether to kill cells based on signals from activating and inhibitory receptors on the NK cell surface. While activating receptors 'switch on' the NK cell when recognizing cell-surface molecules expressed on cancer cells, inhibitory receptors 'switch off' the NK cell and prevent it from killing cells pos-
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