According to the figures of World Health Organization (WHO), over 81 million units of blood are collected annually worldwide, but only 39% are collected in developing countries, which have 82% of the world's population. [2] A blood bank plays an important role in ensuring the supply of safe blood as and when required. Although it is important to ensure that there is an adequate supply of blood, it is also essential that the blood collection process does not harm either the donor or the recipient. This is achieved by having donor deferral criteria [3] and stringent screening of collected blood for possible transfusion transmissible infections (TTIs). [4] Deferrals are divided into permanent and temporary. Few studies conducted in India in the past have provided different common reasons for deferral of whole blood donors, highlighting differing demographic profile in different parts of the country. [5,6] The aim of our study was to know the profile of the blood donors and causes of the permanent and temporary deferral and their frequency. This prospective study was conducted in the blood bank of C.U.