Lime peel (Citrus aurantifolia) contains flavonoids as antioxidants that prevent free radicals, and antioxidants are used to repair skin cells damaged by free radicals. Therefore, a research was conducted with the aim of formulating antioxidant cream preparations using lime peel extract. The extraction was carried out by maceration using ethanol 96% solvent, which was then fractionated with ethyl acetate as solvent. The ethyl acetate extract obtained was formulated into cream preparations with extract concentrations of 3%, 6%, and 9%. The formula obtained was tested for its physical and stability, and then for its antioxidant activity. The results showed that the physical properties of the cream preparation meet with requirements for the physical stability based on the organoleptic test parameters, homogeneity, pH and viscosity. Similarly, the antioxidant activity test of cream against the DPPH free radicals showed that formula 1 with an extract concentration of 3% gives an average IC50 value of 28.24 mg/ml; formula 2 with an extract concentration of 6% gives an average IC50 value of 22.97 mg/ml; and formula 3 with an extract concentration of 9% gives an average IC50 value of 14.80 mg/ml. Based on the results, it was concluded that the lime peel extract are formulated into a cream preparation with type M/A. Formula 3 with an extract concentration of 9% is the best formula with the greatest antioxidant activity.
Palm date fruits (Phoenix dactylifera L) have been used for medical treatment, one of the medical purpose as antioxidant, which is the coumpound for free radical scavenging. In this study used palm juice makes with non sentrifuged method by grounds 200 grams of palm fruit with 20 ml of aquadest and store in room temperature. For date palm syrup used in this study were from certain brand distributed on the market. Antioxidant activity was testing by using DPPH method and determined by spectrophotometry Uv-Vis in wavelength 517nm, and Total Phenolic Content was testing by Folin Ciocalteu method and determined by spectrophotometry Uv-Vis in wavelength 774nm. 11 sample of date palm syrup was sampling by purposive sampling methods and then got 2 sample to tested. Date Palm Juice were made by Non Cetrifuged methods. All sample were tested antioxidant activity using DPPH and Total Phenolic Content using Folin Ciocalteu. This study obtained that best operating time for all sample in antioxidant activity is 30 minutes with the highest point is Date Palm Juice 91,54%, Sample X for 86,93% and Sampel Y 89,92%. There was a linear correlation between with the result Total Phenolic Content for Date Palm Juice 9,25 mgGAE/g, Sample X 4,13 mgGAE/g and Sampel Y 4,28 mgGAE/g. Date Palm Juice and Date Palm Syrup could scavenge free radical DPPH in huge concentration and contain phenolic compound.
The results of previous studies on each concentration of 4000 ppm SPF value of sunscreen cream corncob extract (Zea mays L.) of 5.40. and SPF value of coffee bean extract cream (Coffea canephora Pierre ex A. Froehner) of 8.54. Both of these plant research results have SPF values that are still below 8 -15, so that further research is carried out using a mixture of the two extracts on a sun cream basis based on M / A basis. Methods: Making extracts of corncob mixture and Robusta coffee using a dose of 10%, and 15% and using a type A/M cream base. Cream testing includes physical and stability tests. Determination of the effectiveness of sunscreen cream preparations is done by testing the SPF value, antioxidant content and total phenolics in vitro using a UV / Vis spectrophotometer. Results: Cream stability test meets cream requirements. Formula 1 has an IC50 value of 198.61 ppm, a total phenol of 46 mGAE / g, at an SPF value of 35. Formula 2 has an IC50 value of 101.57 ppm, a total phenol of 59.9 mGAE / g, an SPF value of 38. Formula 3 has an IC50 value of 150.26 ppm, a total phenol of 51.45 mGAE / g and SPF 37. Conclusion: Sunscreen cream corn cobs extract and Robusta coffee has good stability, strong antioxidants, the highest phenol in formula 2, and are categorized as ultra sunblock
Etlingera elatior (E. elatior) plant has long been used as a kitchen spice and daily food. E. elatior has potential as an antioxidant because it contains polyphenol and flavonoid compounds widely found in the leaves, fruit, and flowers. This study measures the total flavonoid content, total phenol content, and antioxidant activity using the ABTS method. Total phenol content was determined by the Follin-Ciocalteu method and total flavonoid content was determined by the Aluminium Chloride method. The results showed that the total flavonoid content from the highest to the lowest value from E. elatior was fruit extract, leaf extract, and flower extract, respectively. The value of total flavonoid content was 8.38 ± 0.15; 4.86 ± 0.10; and 2.60 ± 0.04 % w/w Catechin Equivalent (CE). The total phenol content from the highest to the lowest value from E. elatior was fruit extract, leaf extract, and flower extract, respectively. The total phenolic content values were 54.48 ± 1.89, 46.20 ± 0.83, and 4.80 ± 0.53 % w/w Gallic Acid Equivalent (GAE). The highest to lowest antioxidant activity values (IC50) were leaf extract at 58.82 ppm (strong activity), fruit extract at 103.05 ppm (moderate activity), and flower extract at 251.40 (weak activity), respectively.
Severe acute respiratory syndrome coronavirus-2 (SARS-nCoV-2) the cause of Coronavirus Disease 2019 (COVID-19) was first discovered in Wuhan on December 2019, has spread throughout the world. Each country tries to develop treatment protocol guidelines following the latest research developments to increase the cure rate due to the absence of standard guidelines.The purpose of this research is to knowing the profile of prescribing COVID-19 drug therapy in inpatients at jakarta haji hospital the period September 2020-February 2021. This research is non-experimental with quantitative descriptive study design was taken retrospectively using secondary data in the form of prescription data history of COVID-19 patient visits recorded on the system with sampling techniques that is total sampling. The results showed that in total 387 COVID-19 patients the most were 46-65 years oldwith 198 patients and the mostly malewith 212 patients. The longest duration of treatment was 3-10 days as many as 246 patients and the highest degree of disease was mild to moderate as many as 363 patients The most widely prescribed drugs were Paracetamol (84.37%), Dexamethasone (78.4%), Osetalmivir (74.1%), Heparin (67.81%), Alprazolam (60.27%), Acetylsitein (58 ,12%), Insulin (54.93%), CTM (53.13%), Amlodipine 50.43%, Vitamin C (48.04%), Levofloxacin (35.48%), and Omeprazole (31.98 %). COVID-19 patients at the Jakarta Haji Hospital receive the main therapies, namely vitamins, antibiotics, antivirals, respiratory drugs, gastrointestinal drugs. The suitability of prescribing drug therapy classes based on the guidelines for the management of COVID-19 is 83% and those that are not in accordance with the guidelines are 27%.
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