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Sensitization to BAK and BEC, although rare, does occur. Weak and morphologically irritant reactions at day 7 reading can be relevant. We recommend testing to BAK 0.15% aq and 0.15% pet to increase sensitivity and having patients undergo long-term follow-up.

Aims-Following a short term fast lactating women have increased rates of glucose production but not gluconeogenesis despite relative hypoinsulinemia. We explored the effects of non-insulin dependent increase in glucose utilization and rhGH on glucose production, glycogenolysis and gluconeogenesis in both the fed and overnight fasted condition.Method-Six controls and seven lactating women were studied twice, in random order, following seven days of saline or rhGH. Glucose kinetics and gluconeogenesis (GNG), were measured using [U-13 C]glucose MIDA.Results-RhGH increased milk production in the lactating women and IGF-I in both groups. Glycogenolysis and GNG were higher in fasting lactating women than controls following either saline or rhGH (p<0.05). Following rhGH administration, GNG remained higher (p<0.02) in the lactating women than controls. Gluconeogenesis was not suppressed in either group during 5 h of continuous meal ingestion, despite a 5 fold increase in plasma insulin. Lactating women had similar glucose but lower insulin and C-peptide concentrations than controls following both rhGH and saline treatment (p<0.01), although RhGH decreased (p <0.01) insulin sensitivity in both groups (p <0.05).Conclusions-Gluconeogenesis is not affected by short term increases in insulin and/or rhGH and suggests a fundamental rethinking of the role of insulin in acutely regulating gluconeogenesis.