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The use of d‐lysergic acid diethylamide, LSD, as a reference standard for the evaluation of psychopathologic symptoms was tested. A group of healthy male volunteers took weekly doses of LSD in order to become familiar with the temporary mental changes induced by the drug. The subjects were able to identify three dose levels of LSD and to differentiate LSD from placebo and other drugs. A standard curve of the responses to LSD could be constructed for these subjects. A combination of reserpine plus iproniazid was found not to produce LSD‐like psychopathologic symptoms. The addition of reserpine and iproniazid to LSD did not change the degree or intensity of LSD‐induced psychopathologic symptoms in man.

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