Metals play crucial physiological roles, but they can also cause irreparable toxic effects through binding to important cellular biomolecules in aquatic organisms.

The purpose of this study was to investigate ozone, variations, and its correlation with meteorological parameters at a remote location on the Mali Lošinj Island, which has been a tourist and health resort area in the northern Adriatic. The measured data are discussed in relation to the EU guidelines (Directive 2002/3/EC; Directive 2008/50/EC). In order to characterize ambient air with respect to ozone vegetation injury and photochemical pollution, we calculated accumulated dose over a threshold of 40 parts per billion index and two photochemical pollution indicators. The influence of local meteorological parameters on the measured ozone volume fractions was also investigated. We used the multivariate technique principal component analysis to trace correlations between measured ozone concentration and meteorological parameters.

Gangliosides serve as antitumor therapy targets and aberrations in their composition strongly correlate with tumor growth and invasiveness. Anaplastic ganglioglioma is a rare, poorly characterized, malignant neuronal–glial tumor type. We present the first comparative characterization of ganglioside composition in anaplastic ganglioglioma vs. peritumoral and healthy brain tissues by combining mass spectrometry and thin-layer chromatography. Anaplastic ganglioglioma ganglioside composition was highly distinguishable from both peritumoral and healthy tissue despite having five to six times lower total content. Ten out of twelve MS-identified ganglioside classes, defined by unique glycan residues, were represented by a large number and considerable abundance of individual species with different fatty acid residues (C16–C24) in ceramide portions. The major structurally identified class was tumor-associated GD3 (>50%) with 11 species; GD3 (d18:1/24:0) being the most abundant. The dominant sphingoid base residue in ganglioside ceramides was sphingosine (d18:1), followed by eicosasphingosine (d20:1). The peritumoral tissue ganglioside composition was estimated as normal. Specific ganglioside composition and large variability of ganglioside ceramide structures determined in anaplastic ganglioglioma demonstrate realistic ganglioside expression patterns and correspond to the profile of high-grade malignancy brain tumors.

Abstract. Result of the first ozone monitoring in ambient air Nature Park of Kopački Rit (Eastern Croatia) are reported for the growth season in 2008. The measured hourly concentrations of ozone in the air do not exceed the limit value of 110 μg m -3 statutory regulation by Croatian legalization for the protection of human health. There were only 13 days exceeding of the target value of 120 μg m -3 (8-h averages) as established in the European Union guidelines on ozone pollution in ambient air. In contrast to the measured AOT40 whose value does not exceed the critical level of 18 000 (µg m -3 ) · h for vegetation injury, an estimated AOT40 value was somewhat higher. The relationships between O 3 and meteorological variables were investigated by a principal component analysis (PCA). Fourier analysis methods applied to ozone concentrations data showed that the most important variations in the O 3 data are represented by usual daily cycles. (doi: 10.5562/cca2147)

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