Krabbe disease is a neuro-regressive disorder commonly seen in the infantile age group. The authors report a four-month-old male baby with persisting irritability despite adequately treated for meningitis. The authors wish to highlight the importance of systematic evaluation that leads to the diagnosis of Krabbe disease, which can be challenging in the early infantile age group.

Background: Intussusception is a rare cause of bleeding per rectum in neonates. Duplication cyst as a pathological lead point for intussusception is rarer too. Case Presentation: A female neonate presented with bilious vomiting and bleeding per rectum. Ultrasonography diagnosed it as intussusception. Intraoperatively, on reduction of intussusception, a mass was found which on histopathological examination (HPE) revealed a duplication cyst. Conclusion: A high index of suspicion is required for an early diagnosis of neonatal intussusception, which is essential for preventing complications and mortality.