Infertility is a disease of the reproductive system characterized by inability to achieve pregnancy after 12 or more months of regular unprotected sexual intercourse (Venkatesh et al., 2014). Female infertility, as a complex disorder, may be caused by medical conditions including pelvic inflammatory disease, endometriosis related infertility, ovulatory disorders, tubal factor infertility, and unexplained infertility(Gupta  et al., 2014). Infertility affect approximately nine to fifteen percent of the childbearing population, and 55% of these influenced will seek medical help to achieve their desire to have children (Boivin et al., 2011).

The sulfation of the adrenal steroid dehydroepiandrosterone (DHEA) is a critical step in the provision of substrates for estrogen biosynthesis by the placenta during pregnancy.     Dehydroepinadrosterone (DHEA) supplementation improves pregnancy chances in women with diminished ovarian reserve (DOR), by possibly reducing aneuploidy. Defects in the synthesis of DHEA cause deficiencies in the synthesis of androgens and estrogens. In the first stage, mutations in the StAR gene cause potentially lethal lipoid CAH. Defects in the cholesterol side chain cleavage enzyme, the second step, are rare. Defects in the third stage, 17-hydroxylation lead to hypertension and female sexual infantilism. Defects in the final stage of DHEA synthesis, 17, 20 lyase activity, are due to disorders of electron transfer to P450c17, including mutations in POR