This study was carried out to determine the problems and educational needs of cancer patients due to the port catheter. Between January and March 2018, 100 cancer patients over 18 years of age with a port catheter were enrolled. The data was collected through a data collection form consisting of 29 items examining the sociodemographic and port catheter-related problems of patients. It was determined that 14% of patients had problems, 64.3% had infections, 21.4% had catheter exposure, and 14.3% had a displacement of catheter. Primary school graduates stated that they had more problems during catheter use and care, compared to high school and university graduate patients (p=0.037). Male patients were found to have more problems than female patients (p=0.039). In this study, it was observed that patients with cancer were inadequate to maintain home care of the port catheter and therefore experienced complications that could threaten their health, especially infection. It is recommended that patients be given practical training about the maintenance of the port catheter by specially trained nurses.