Objective: Infants of diabetic mothers (IDM) are considered as a risk group for atherosclerosis. Increased aortic intima-media thickness has been reported in IDM. The purpose of this study was to assess carotid artery intima-media thickness (CA-IMT), left ventricular mass index (LVMI) and atherosclerotic risk factors in IDM. Methods: Thirty IDM and 25 healthy controls were included in the study. Of these infants, 14 were appropriate-for-gestational age (AGA) and 16 were large-for-gestational age (LGA). CA-IMT and LVMI were obtained by M-mode echocardiographic examination. The relationship between parameters of atherosclerosis and echocardiographic measurements was assessed by Pearson’s correlation analysis. Results: LVMI was higher in LGA IDM when compared to AGA IDM and controls. CA-IMT was not significantly different between the groups and was also not related to atherosclerotic risk factors. Serum lipid and insulin levels were higher in LGA IDM when compared with AGA IDM and controls. There were no correlations between CA-IMT, LVMI and atherosclerotic risk factors. Conclusions: In contrast to previous reports indicating an increase in CA-IMT in IDM, no differences were found between IDM and controls in this study. Our results indicate that macrosomic IDM are prone to hypertrophic cardiomyopathy but not to atherosclerotic changes in the blood vessels. Conflict of interest:None declared.

BackgroundAcute diarrhea is the second most common cause of morbidity and mortality worldwide, especially in children aged ≤3 years. Some drugs (e.g., the mucoprotector gelatin tannate) plus a reduced osmolality oral rehydration solution (ORS) may effectively reduce symptom duration and severity. The current trial was therefore designed to assess the efficacy and safety of gelatin tannate in pediatric patients with acute diarrhea.Material/MethodsThis was a randomized, controlled, double-blind, parallel-group, single-center study comparing gelatin tannate plus ORS (103 patients) with ORS plus placebo (100 patients) in children aged 3 months to 12 years with infectious or noninfectious acute diarrhea. Details about stool consistency and total time to resolution of diarrhea comprised the primary study endpoints. Secondary study endpoints included symptoms of diarrhea at 12, 24, 36, 48, and 72 hours after the first dose of study medication.ResultsFrom 12 hours onwards, the incidence of watery stools was significantly lower in the gelatin tannate group than in the ORS group (at 12 hours: 59.2% vs. 77.0%; p=0.01). The same was true for stool frequency (at 12 hours: mean 2 vs. 3 stool productions in the previous 12 hours; p<0.01). At all timepoints during the study, the proportion of patients with Stool Decrease Index improvement was significantly greater (p<0.01) in the gelatin tannate group than in the placebo group (at 12 hours: 66.6% vs. 33.3%; p<0.01).ConclusionsGelatin tannate plus ORS is an effective and safe option for the treatment of acute diarrhea in children. Significant symptom relief is evident 12 hours after starting treatment.

Kronik rekürren multifokal osteomiyelit (KRMO) etyolojisi tam aydınlatılamamış, nadir görülen enfeksiyöz olmayan enflamatuvar kemik hastalığıdır. Hastalık tekrarlayan kemik ağrısı ve ateş atakları ile seyreder. Klinik olarak bakteriyel osteomiyeliti taklit etse de kültürlerde üreme olmaz ve antibiyotik tedavisine yanıt vermez. Bu yazıda bilateral kronik bacak ağrısı ve şişlik şikayeti ile başvuran ve KRMO tanısı alan 11 yaşında bir kız olguyu sunduk. Bu olgu sebebi ile tekrarlayan, multifokal kemik ağrısı olup osteomiyelit kliniği olan hastalarda KRMO'nun ayrıcı tanıda düşünülmesi gerektiğini vurgulamak istedik.

Kronik rekürren multifokal osteomiyelit (KRMO) etyolojisi tam aydınlatılamamış, nadir görülen enfeksiyöz olmayan enflamatuvar kemik hastalığıdır. Hastalık tekrarlayan kemik ağrısı ve ateş atakları ile seyreder. Klinik olarak bakteriyel osteomiyeliti taklit etse de kültürlerde üreme olmaz ve antibiyotik tedavisine yanıt vermez. Bu yazıda bilateral kronik bacak ağrısı ve şişlik şikayeti ile başvuran ve KRMO tanısı alan 11 yaşında bir kız olguyu sunduk. Bu olgu sebebi ile tekrarlayan, multifokal kemik ağrısı olup osteomiyelit kliniği olan hastalarda KRMO'nun ayrıcı tanıda düşünülmesi gerektiğini vurgulamak istedik.

No abstract