Viral agents that cause disease in the respiratory system have led to widespread health problems in the world. The continuation of mutations in these viruses and the lack of an effective treatment agent bring possible public health risks. In this study, the virucidal activity of potassium hydroxide (KOH) was evaluated. The intermolecular interactions of KOH and envelope-structured molecules in enveloped viruses and the virucidal activity of these interactions on Tospovirus, which has the ability to infect, were evaluated. For this study model, the intermolecular interactions of KOH in the lipid bilayer of the virus envelope were evaluated in silico by Doking method. Then, the plant virulence ability of Tospovirus was observed by the direct interaction of KOH with Tospovirus. It was observed that KOH interacted exergonically with the glycerophosphate structure in the envelope structure. It was determined by clinical and laboratory observations that Tospovirus in plants lost its virucidal activity after interaction with KOH. In the light of this information, it was thought that KOH had a virucidal effect in enveloped viruses. It is thought that KOH creates this virucidal activity by KOH-glycerophosphate intermolecular interactions and viral envelope lipid layer hydrolysis. The mucolytic, alkalinizing and possible low-weight immunoglobulin-forming potential of KOH has been demonstrated in previous studies and no pathology was detected in toxicity studies in mice. In the light of this information, optimized KOH inhalation has a very serious potential as a virucidal agent in diseases caused by enveloped viruses in the respiratory system such as Coronavirus, H. influenza.