This study includes formation Schiff bases compounds [A1- A3] were synthesis from raction4-aminoantipyrine with many aromatic aldehydes [4- chloro benzaldehyde, 4-bromo benzaldehyde and 2-hydroxy1-naphthaldehyde] in absolute ethanol. These compounds [A1-A3] has been characterized by melting points, [FT.IR] spectroscopy, thin layer chromatography technique (TLC) has been used for reactions steps and sequence by using solvent (ethyl acetate:toluene, 1:4). Antibacterial activity test was done according to agar well diffusion method against two types of multi-drug resistance of bacteria isolated from patients with infection of urinary tract. Three concentrations were prepared for each compound (50, 100 and 150) mg/ml. The results proved that derivative compound A3150 mg/ml provided the best antibacterial activity against K.pneumoniae with inhibition zone diameter 21± 0.25mm and against C.freundii 22± 0.5mm as compared with other derivatives compounds.

ABSTRACT

Schiff bases derivatives are one of the most important compounds that have been used in many biological applications such as antimicrobial activity. Pseudomonas aeruginosa and Staphylococcus aureus are two of the most important pathogenic bacteria that cause wound infection in Iraq and many developing countries. This research involves a synthesis of some Schiff bases compounds [A1 – A3] that were prepared from the condensation of [4- chlorobenzaldehyde, 4-bromobenzaldehyde, and 4-hydroxybenzaldehyde] in absolute ethanol. All of these compounds are characterized by [FTIR] spectroscopy. The antibacterial activity test was done according to agar well diffusion method for all derivative compounds with a concentration of 100 mg/ml and 200 mg/ml for each compound. The derivative compound A3 with a concentration of 200 mg/ml had an excellent antibacterial effect against Pseudomonas aeruginosa and Staphylococcus aureus with a diameter of inhibition zone of 18.417 ± 0.54645 and 16.000 ± 0.57735, respectively. Schiff bases derivatives synthesis compounds in this study (A1 and A2) can be considered as suitable antibacterial materials and can be used as raw materials to the synthesis of new ointment.