One important element in an organization is human resources, where the organization will be effective and efficient if it has qualified human resources. The effectiveness and efficiency of an organization is determined by the performance produced by members of the organization as a representation of the organization. While the factors that affect the performance of a variety of, one of which values reflect the behavior of organizational members. The values possessed by members of the organization are the result of religious beliefs that are reflected in their spiritual life. The purpose of this study was to examine the effect of workplace spirituality on employee performance, the relationship of workplace spirituality on employee performance in this study based on the influence of Islamic work ethics, with the sample in this study were employees of BTPN Syariah, Kupang. The results showed that workplace spirituality had a significant effect on employee performance, the relationship between workplace Spirituality (STK) on employee performance was based on Islamic work ethics adopted in BTPN Syariah.