This article highlights the issues of reforming the sphere of karakul breeding in Uzbekistan, in particular, the development of a small zonal karakul breeding complex and the objective features of improving this important area as a result of inter-farm cooperation and specialization, as well as new optimal ways of using, ensuring employment in rural regions and the development of family entrepreneurship. The general and main development goal of the whole sub-complex is the search for promising directions for using the production potential of regional karakul breeding sub-complexes. In this case, the need to organize effective production in the conditions of modernization and localization of the economy, replenishment of Uzbekistan's foreign exchange fund and demand for natural fur market should be taken into account. In addition, it should be based on ensuring that the prestige of high-quality karakul leather increases. In the implementation of this goal, on the basis of specialized breeding, the karakul maintains a scientifically based system of breeding. In the agricultural sector, four main types of karakul breeding agro-farms - breeding enterprises, breeding agro-reproducers, commodity agro-farms, and inter-farm karakul should be maintained and restored in special complexes.