Natural health products, are popular with patients due to their ease of access and perceived margin of safety. This study aimed to prepare a functional yoghurt and study its effect on osteoporosis rats injected with dexamethasone. Thirty five adult male albino rats were divided into two main groups, the first group (n = 5) as a normal control group, while the second group (n =30) were injected with dexamethasone (1 ml/100g) to induce osteoporosis once a day for 6 weeks. The second main group was divided into six subgroups (n = 5). Subgroup 1 was fed on basal diet as a positive control. Subgroups 2, 3 ,4 ,5 and 6 were fed on soymilk, soymilk yoghurt, soymilk yogurt with pomegranate fruit, soymilk yogurt with persimmon fruit and soymilk yoghurt with kiwi fruit respectively. Result showed that soymilk yoghurt fortified with fruits was rich in minerals, vitamins and lactic acids. Also the rats suffering from osteoporosis and treated with soymilk yoghurt fortified with fruits led to decrease in cholesterol, triglycerides, LDL-c, ALT, AST, total protein, total bilirubin, creatinine, urea, uric acid, MDA and serum P levels as well as urine Ca and increased HCL, HDL-c, SOD, GPx, CAT, serum Ca and Vitamin D, especially with soymilk yoghurt with kiwi.