Aim: to evaluate the shear bond strength of an adhesive system (Single bond universal adhesive+ RelyX Ultimate cement) and Panavia F2.0 to two types of zirconia (conventional ZI zirconia and translucent TZI zirconia) after thermocycling. Materials & Methods: 10 square shaped large samples from Incoris ZI blocks, and 10 from Incoris TZI blocks were prepared with larger dimensions (12x12x2mm). Another 10 square shaped small samples from each type of zirconia blocks were with small dimensions (6x6x2mm). The surfaces of the large and small samples were air abraded with 110 µm AL2O3 particles, then each small sample was bonded to the large sample using two types of cements (RelyX Ultimate cement in combination with Single bond universal adhesive and Panavia F2.0 cement) under 3Kg load and light cured. After bonding, all specimens were thermocycled for 5000 cycles. The cement/ zirconia interface for each subgroup was detected under scanning electron microscope and the shear bond strength was tested using a computerized universal testing machine. Results: No significant difference between shear bond strength of all subgroups tested. Conclusion: The shear bond strength of RelyX Ultimate+ Single bond universal adhesive to two types of zirconia was comparable to Panavia F2.0 , and the shear bond strength of translucent zirconia bonded with two types of cements was comparable to conventional zirconia.