The trigeminal trophic syndrome (TTS) is a rare form of cutaneous ulceration characterized by anesthesia, paresthesia and a secondary persistent facial ulceration. It is uncommon in children. However, we report an unusual case of TTS in a 5- year-old child with Moebius syndrome ,extending over the right nostril and then the other nostril was infected. The diagnosis of TTS was based on clinical history, tissue biopsy and serologic evaluation. The ulcer was treated with multiple antibiotics with no improvement. We describe this case because of very few pediatric cases of TTS published in the past , and to increase the awareness of this syndrome among dermatologists.

Granuloma faciale is a rare chronic skin disorder characterized by asymptomatic papules, nodules, and plaques on the face. Although its pathogenesis is unknown, researchers have suggested that one of the main causative factors may be sun exposure, as lesions are aggravated by sunlight and favor light-exposed areas. Herein, we are reporting the case of an adult female patient with keloidal granuloma faciale treated with a combination of several treatment methods with no improvement and a relapse. In this case, we attempted to highlight the difficulties that the doctor faces in treating the disease and to share the medical literature of our treatment experience.

PAPASH syndrome is a rare autoinflammatory syndrome consisting of four essential components: pyogenic arthritis (PA), pyoderma gangrenosum (PG), acne (A), and suppurative hidradenitis (SH). The true etiology is unknown, yet genetic analysis has shown associations with PSTPIP1 mutations, which ultimately lead to elevations in interleukin-1 activity. Herein, we report a case of painful ulcers in a 47-year-old Syrian male located on the legs and swelling of both ankles, with a bad condition and hyperthermia. He also had a history of acne, suppurative hidradenitis, fistulas, and abscesses in the buttock area. The results of skin biopsy, laboratory testing, joint aspiration, and poor responding to antibiotic treatment excluded the infective nature of the case. To our knowledge, this was the first case of PAPASH syndrome diagnosed in Syria. Key words: PAPASH syndrome; Pyoderma gangrenosum; Hidradenitis suppurativa; Hereditary autoinflammatory diseases; Acne