The business competition among chemical companies is more and more fiercely with the development of the society. The output, cost, quality of the industrial products are attracting more attention. Digital factory(DF), based on the date of the whole product life cycle, is a new production organization which simulate the production cycle, evaluating and optimizing the whole production process in the computer virtual environment. DF is also a combination of the modem digital manufacturing technology and the computer simulation technology that bridges the product design and manufacturing. As a rising star of the Global manufacturing. In this paper we introduced the features and key technologies of Digital Factory and established a Digital Factory plan according to domestic chemical industry. We also analyzed the problems that the Digital Factory confronted in chemical industry spreading.