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The case histories, treatment and post–operative progress of 297 dogs referred to this Department for investigation of stifle conditions between September 1968 and September 1972 are described with particular emphasis on the long term results of treatment. Résumé. Les antécédents commémoratifs, le traitement et les progrès postopératoires de 297 chiens, remis à ce département entre Septembre 1968 et Septembre 1972 pour investigation à l'égard de l'état du grasset, ont été décrits en mettant surtout l'emphase sur les résultats thérapeutiques à long terme. Zusammenfassung. Nachdrùcklich der langfristigen Behandlungsfolgen von Kniegelenke‐Zustànden, sind Befunde, Behandlungen und postoperative Fortschritte der, von den zwischen September 1968 und September 1972 diesem Abteil zum Forschungszweck iiberreichten 297 Hunde, mit besonderem Hinweis auf Endergebnisse, dargestellt.

In vitro skin absorption methods exist in Organisation for Economic Co-operation and Development (OECD) guideline form (No. 428) and are used to estimate the degree of systemic penetration of chemicals through skin. More detailed kinetics of permeation through skin compartments are not described well by existing methods. This study was designed to assess the practical feasibility of generating compartmental (stratum corneum/epidermal/dermal) disposition and kinetic data of topically applied chemicals. For chemically induced effects initiated in the skin (e.g., skin allergy), the delivery of tissue concentrations of chemical will impact the incidence and severity of biological effect. Explicit data on the kinetics of chemical disposition in skin have not traditionally been needed for skin allergy risk assessment: current in vivo assays embody delivery implicitly. Under the 7th Amendment to the European Cosmetics Directive, in vivo assays (such as the local lymph node assay for skin sensitization) will not be permitted to assess cosmetic ingredients. New in vitro and in silico alternative approaches and ways of predicting risk of adverse effects in humans need to be developed, and new methods such as that described here provide a way of estimating delivered concentrations and the effect of formulation changes on that delivery. As we continue to deconstruct the contributing factors of skin allergy in humans, it will be useful to have methods available that can measure skin tissue compartment exposure levels delivered from different exposure use scenarios. Here we provide such a method. The method could also be used to generate useful data for developing in silico kinetic models of compartmental skin delivery and for refining data for skin delivery in relation to the evaluation of systemic toxicity.

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Three cases of gas gangrene in the dog are described. Symptoms followed fracture of a femur in two cases and amputation of a hindlimb in the third. Clostridium welchii was isolated in each case. Two animals recovered following drainage of the lesion together with local and parenteral administration of the appropriate antibiotics. Résumé. On décrit trois cas de gangrène gazeuse chez le chien. Des symptômes ont suivi une fracture du fémur dans deux cas et une amputation dans le troisième. On a isolé un Clostridium welchii dans chaque cas. Deux animaux se sont rétablis après drainage de la lésion avec à la fois une administration locale et parentérale des antibiotiques appropriés. Zusammenfassung. Drei Fälle von Gasgangrän in Hunden sind beschrieben. In zwei Fällen folgten Symptome einer Oberschenkelfraktur und in einem dritten Fall einer Amputation. Clostridium welchii wurde in jedem Fall isoliert. Zwei Tiere erholten sich nach Dränage der Läsion kombiniert mit örtlicher und parenteraler Verabreichung der entsprechenden Antibiotika.