Background: Riproximin is a cytotoxic lectin from Ximenia americana showing tumor selectivity. Results: Riproximin selectively binds to two types of glycoconjugates present on glycoproteins, cross-linking them by its two binding sites.
Conclusion:The biologic activity of riproximin is determined by specific and dynamic interactions with multivalent, cancerrelated glycan targets. Significance: The selectivity of riproximin for cancer cells relies on its unique targeting mechanism.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.