Science diplomacy has been an endeavoured area of cooperation between Sweden and South Africa despite Sweden’s reluctanceto practice science diplomacy. However, the introduction of the South Africa-Sweden University Forum (SASUF) in 2017 remains an underexplored phenomenon of knowledge diplomacy. Using Knight’s five characteristics of knowledge diplomacy (focus on higher education, research, and innovation; diversity of actors and partners; recognition of different needs and the collective use of resources; reciprocity; and the building and strengthening of relations between states), this paper argues that SASUF is an essential frontier for knowledge diplomacy in the context of South Africa-Sweden relations. The employment of Knight’s framework finds that SASUF can indeed be classified as an example of knowledge diplomacy. In conclusion, a new research agenda on knowledge diplomacy within the context of South Africa-Sweden relations is proposed.