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The antimicrobial resistance has significantly risen in last few decades as a result of too much usage of antibiotics. In the case of failure of drug therapy, the multidrug resistance has become a serious issue in a clinical and food sectors. The rapid emergence of antibiotic resistance has become a great concern for public health worldwide. Therefore, the novel approaches of nano-biomaterials (NBM) and bacteriophage (phage) have received a new attention as an alternative treatment for antibiotic-resistant bacterial infections. Moreover, the advanced molecular biology and genetic engineering have been successfully applied for the rapid detection and control of multidrug resistant pathogenic strains. This chapter specifically summarizes the prevalence of common as well as under-researched antimicrobial resistance of bacterial pathogens and the application of nano-biomaterials and bacteriophage to fight against antimicrobial resistance. Ultimately, the synergistic approach will be a highly promising prospect to threat of antimicrobial resistance.

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