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Automated retinal layer segmentation of optical coherence tomography (OCT) images has been successful for normal eyes but becomes challenging for eyes with retinal diseases if the retinal morphology experiences critical changes. We propose a method to automatically segment the retinal layers in 3-D OCT data with serous retinal pigment epithelial detachments (PED), which is a prominent feature of many chorioretinal disease processes. The proposed framework consists of the following steps: fast denoising and B-scan alignment, multi-resolution graph search based surface detection, PED region detection and surface correction above the PED region. The proposed technique was evaluated on a dataset with OCT images from 20 subjects diagnosed with PED. The experimental results showed the following. 1) The overall mean unsigned border positioning error for layer segmentation is 7.87±3.36 μm , and is comparable to the mean inter-observer variability ( 7.81±2.56 μm). 2) The true positive volume fraction (TPVF), false positive volume fraction (FPVF) and positive predicative value (PPV) for PED volume segmentation are 87.1%, 0.37%, and 81.2%, respectively. 3) The average running time is 220 s for OCT data of 512 × 64 × 480 voxels.

Bias stability is an important performance indicator for MEMS gyroscopes. In this paper, a gyroscope zero rate output (ZRO) model under force-to-rebalance (FTR) closed-loop detection is presented, and the effect of circuit phase delay and various noises on the ZRO is analyzed. Based on the fact that the two feedback forces in the FTR system are insensitive to the phase delay of the sense mode, while they are sensitive to the phase delay of the drive mode, a method for quickly calculating the circuit phase delay is proposed, and an all-pass filter is used to realize one-time automatic compensation for the phase delay in the drive mode. The control system is implemented with an FPGA. The experimental results show that this method can be used to accurately calculate the circuit phase delay and that phase compensation can be used to effectively reduce the effect of quadrature error on ZRO. This technique provides bias instability and angle random walk performances of 0.338° h −1 and 0.061 ° (√h) −1 , respectively. In addition, the sensitivity of ZRO to temperature at 0 °C to 70 °C has reached 0.001°/s/°C.

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