Key words:Psoroptes spp. mites, Ivermectin, Permethrin, Benzyl benzoate, Crotamiton A total of 30 water buffalo calves at smallholder farm suffering from skin lesions and clinical signs compatible with mange were investigated clinically and parasitologically. The efficacy of three topical drugs with ivermectin in the treatment of psoroptes mites was inspected. Infested calves were randomly allocated into four groups (6 calves each) in addition to positive untreated control group. The four un-control groups were administered ivermectin 1mL/50kg body weight by a single subcutaneous injection. Three groups were treated with different topical agents including benzyl benzoate 25%, crotamiton 10% and permethrin 5% once daily for two consecutive days. The number of live mites in skin scrapings was determined prior to treatment and at weekly intervals for eight weeks post treatment. Severity of skin lesions was evaluated and scored. The synergistic effect of each topical agent with ivermectin were compared for eliminate mites, aiming to obtain the ideal treatment model. Mite counts of the treated animals with Ivermectin plus permethrin were significantly (p < 0.05) lower than those of the Ivermectin plus benzyl benzoate at 2 weeks post-treatment. The efficiency of ivermectin plus permethrin was found to be significantly more effective in the treatment of mange even in the first days after application compared with other groups. Permethrin is a good and easily applied topical drug for treatment of psoroptes mites infestation in buffalo calves when used with ivermectin injection.