Utilization of health services is increasing in the era of National Health Insurance (JKN) through referral service. Unfortunately, lack of information of health facilities resources, leading to sub optimal referral services and emergency care. On the other hand, information and communication technology can facilitate referral services through the provision of information of health facilities resource in an area. This research aimed to design an integrated information system to support a referral service and emergency care in DI Yogyakarta province. A qualitative research was conducted in order to analyze the need of information of health facilitiy resources, designing integrated information system and to provide information of health facilities resources electronically. Most of the health facilities, both primary care and hospitals already have an electronic information system. Integrated information system was developed to integrate data of health facilities resource from various existing systems thorugh the web service technology.Keywords: integrated information system, health facility resources, referral services, web service AbstrakDi era Jaminan Kesehatan Nasional (JKN), utilisasi pelayanan kesehatan semakin tinggi melalui pelayanan rujukan berjenjang. Sayangnya ketersediaan informasi sumber daya fasilitas kesehatan menyebabkan pelayanan rujukan dan kegawat-daruratan kurang optimal. Disisi lain, teknologi informasi dan komunikasi dapat memfasilitasi pelayanan rujukan melalui penyediaan informasi sumber daya fasilitas kesehatan di suatu wilayah. Penelitian ini bertujuan untuk merancang sistem informasi terintegrasi untuk mendukung pelayanan rujukan dan kegawat-daruratan medis di DI Yogyakarta. Penelitian dilakukan secara kualitatif untuk menganalisa kebutuhan informasi sumber daya fasilitas kesehatan, merancang integrasi antar sistem informasi secara elektronik, serta penyediaan layanan informasi sumber daya fasilitas kesehatan bagi pengguna. Sebagian besar fasilitas kesehatan, baik layanan primer maupun rumah sakit sudah memiliki sistem informasi elektronik. Sistem informasi terintegrasi dikembangkan untuk mengumpulkan data sumber daya fasilitas kesehatan, dengan mengintegrasikan berbagai macam sistem yang digunakan melalui teknologi web service.Kata kunci: sistem informasi terintegrasi, sumber daya fasiltias kesehatan, pelayanan rujukan, web service