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Precise coronary artery segmentation is a prerequisite for quantitatively assessing the severity of coronary artery stenosis. Extracting the centre line of the 3D volumetric coronary artery tree, also named as 3D skeletonization, plays an important role in identify the variations of cross-sectional profile. Typically there are three skeletonization methods, viz. distance transformation, Voronoi method and topological thinning method. All these three skeletonization methods were applied in this study to extract the curve-skeleton of coronary arteries, after segmenting the coronary artery tree with Hessin filter. Among them, topological thinning method is recommended, as it produces reliable and accurate curve-skeleton for vessels with varying size. This will facilitate quantitative assessment of the severity of coronary artery stenosis, help clinical diagnosis and treatment planning of coronary artery disease.

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