In Ethiopia, the Enset -based farming system is a major agricultural system that serves at least one-fifth of the country’s population. Farmers locally have received knowledge from generations of experience and experimentation that match neighborhood conditions. Yet, the scientific strategies were less used farmers’ Enset (Ensete ventricosum (Welw.) production and protection. This study aimed at assessing farmer’s indigenous knowledge of protecting their Enset crops form disease. The study adopted multistage sampling methods and a total of 135 respondents were selected. The study identifies, “chegino”, “Janfa”, and “quaqusa” as the major and the most important diseases that counteract the Enset production in the study area. Furthermore, the study indicates the traditional disease prevention methods of the community to control the habitually acknowledged Enset disease. Most farmers in the surveyed area use sanitation (37.8 %) or uprooting of infected Enset plants and Dis-budding (31 %) then burn or bury the residue for reducing the spread of the disease. However, crop rotation and rotation of planting holes were applied by few farmers. Besides, this study shows that the death of experienced older folks, climate variability, farmers moving to other crop production, and lack of help to apply local knowledge is the primary imperatives of the farmers to apply native knowledge on the ranchers in the study area. Thus, farmers' indigenous knowledge can be combined with scientific knowledge to improve livelihood of the farmer.