Discussion: Mantle cell lymphoma is a subtype of non-Hodgkins lymphoma (NHL) making up about 7% of NHL in adults. MCL predominantly presents with advanced disease. Gastrointestinal involvement during endoscopic evaluation is rarely the presenting sign, as in this patient, which most commonly manifests as diffuse lymphomatous polyposis. Recognizing this endoscopic finding is important as it can expedite diagnosis by appropriately analyzing tissue obtained through biopsy and attaining further imaging to confirm the suspicion of lymphoma.[2033] Figure 1. A. Nodular ileocecal valve with surrounding polypoid colonic mucosa B. Polypoid mucosa in the terminal ileum C. Lymphoma cells with irregular nuclear contours, irregular chromatin, inconspicuous nucleolus, and moderate amount of cytoplasm. D. CT scan showing 5.0cm ileocecal valve.
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