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8 The terminology which we have been using for some years to describe the various hierarchies of fibrous structures is as follows: the histologically observable fibrous unit of connective tissue is called the "fiber"; the structures observable in the electron microscope as the unit which is crossstriated and usually 500-1,000 A wide is called the "fibril"; when fibrils of collagen are treated with acid, they fray into thinner bundles, the "filaments"; the smallest fibrous units which show all the properties of collagen are called "protofibrils"-they may be one or only a few polypeptide chains in thickness. 9 We are indebted to Dr. Karl Schmid for the preparation of purified a-1 acid glycoprotein obtained from human plasma.10 Glycine was determined by Christenson, Riggs, and Ray's (

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