Abstracf. "he ability of a galactokinase deficient patient to metabolize galactose, galactitol and galactonate was quantitated. In galactokinase deficiency, converaion of galactose to C02 is minimal. Apparently the defect is extemive. involving all tissues. Galactitol and galactonate, injected intravenously, were not metabolized. The adminiitration of C-1 and C-2 labelled galactose resulted in 1 C 0 , excretory patterm similar to that observed in uridyltransferaae deficient mutanta. The different fatea of C-1 and C-2 observed in this galactokixwm deficient patient give eup rt to the existence of a direct oxidative pathway for ga&ose. Galactonate. although preeent in urine during the period of observation following injection of radioactive galactose failed to become labelled.

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The lipid composition of both intracellular and extracellular forms of' the ERA strain of rabies virus grown in BHK/21 cells was determined. The lipids from purified preparations of both intracellular and extracellular virus yielded 57 and 58% neutral lipid, respectively. The phospholipids of the intracellular and extracellular virus constituted 43 and 42%, respectively. Triglyceride and cholesterol appear to be the major neutral lipids, whereas sphingomyelin, phosphatidylethanolamine, and phosphatidylcholine comprise the major bulk of phospholipid in both virus types. The molar ratio of cholesterol to phospholipid was 0.87 (intracellular) and 0.92 (extracellular). On the basis of the data presented, it is reasonable to assume that the lipids of both intracellular and extracellular rabies virus are similar.

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