No abstract

A retrospective study of some 500 biopsies from female cats showed 12 examples of a benign fibroglandular proliferation of the mammary gland. This condition has not been reported in the literature. The lesion resembles pericanalicular fibroadenoma of women and may involve one or more mammary glands in young, intact queens. No statistically significant breed incidence was found. The growths regress with ovariectomy, which suggests hormonal pathogenesis (hyperprogesteronism).

Previous developmental and reproductive toxicity studies conducted in rats with Losartan, a potent AT1 subtype selective angiotensin II receptor antagonist, noted treatment-related effects on the pups of dams treated beyond the second trimester through lactation, as demonstrated by increases in pre- and postweaning pup deaths and decreased pup body weights [Spence et al. (1995) Teratology 51:000-000]. The studies presented here were designed to define the critical period for the induction of neonatal toxicity and to examine the effects of Losartan on kidney development when the drug is administered to the dam beyond the second trimester through lactation. In a developmental toxicity study with postweaning evaluation, pregnant rats were administered 5, 20, and 100 mg Losartan/kg/day on gestation days 6 through 15 (GD 6-15). There were no adverse effects on the F1 generation as assessed by mortality, clinical signs, weight gain, external examinations, developmental signs, behavioral tests, and gross or microscopic examination of the kidney. In a fostering/cross-fostering study, pregnant rats were administered 100 mg Losartan/kg/day on GD 15 through lactation day 20 (LD 20). Following delivery, pups from dams treated with Losartan were fostered to control dams, pups from control dams were fostered to Losartan-treated dams, and pups were also fostered to dams within the same group. Maternal exposure to Losartan during lactation increased the incidence of pup deaths on postnatal days 1-3 (PND 1-3), caused decreased pup weights on PND 7, and decreased performance in the auditory startle test in females and increased performance on the second swim maze test in males, relative to controls. Maternal exposure to Losartan during gestation was associated with decreased pup weight on PND 21 and effects observed on male performance in the swim maze test. Treatment during gestation was also associated with decreased pup cardiac weight as well as drug-induced histopathological changes of the kidneys from F1 pups, including medial hypertrophy of intracortical arterioles and dilatation of the renal pelvis. While the cardiac and renal vascular effects disappeared with time, significant renal lesions were still evident by PND 90. In a late-gestation/lactation study with renal evaluation, pregnant rats were administered 0.5, 1.0, 5.0, 20, and 100 mg Losartan/kg/day on GD 15-LD 20. Maternal toxicity was evident as decreased body weight gain in the 100 mg Losartan/kg/day group.(ABSTRACT TRUNCATED AT 250 WORDS)

Twenty‐two dogs with osseous haemangiosarcoma were examined in the University of Pennsylvania School of Veterinary Medicine from July 1952 to September 1972. A detailed case report of a primary haemangiosarcoma of the proximal humerus in a 21/2‐year old spayed Irish Setter is given along with the salient features of twenty‐one other cases. The three breeds most commonly involved were Boxers, Great Danes and German Shepherd Dogs. The ages ranged from 2–11 years with a median age of 6 years. The male to female ratio was 1·6:1·0. The proximal humerus and ribs were the bones most commonly affected. The long bone to flat bone ratio was 1·0:1·33. In some cases it was difficult or impossible to ascertain whether the haemangiosarcoma in bone was primary or metastatic. Histological grading appeared of little or no prognostic value. Résumé. De juillet 1952 à septembre 1972, on a examiné à l'Ecole de Médicine Vétérinaire de l'Université de Pennsylvanie, vingt‐deux chiens atteints d'hémangiosarcome osseux. On donne un protocole détaillé d'observation d'un cas d'hémangiosarcome primaire de l'humérus proximal chez un setter irlandais châtré avec les traits caractéristiques saillants de vingt et un autres cas. Les trois races les plus communes dont il s'agissait, étaient les Boxers, les Grands Danois et les Bergers Allemands. Les âges variaient de deux à onze ans avec une moyenne d'âge de six ans. La proportion mâle à femelle était de 1·6:1·0. L'humérus proximal et les côtes étaient les os lesplus communément affectés La proportion de l'os long à l'os plat était de 1·0:1·33. Dans certains cas, il était difficile ou impossible de constater si l'hémangiosarcome de l'os était primaire ou métastatique. Une gradation histologique a semblé n'avoir que peu ou pas de valeur prognostique. Zusammenfassung. Zweiundzwanzig Hunde mit ossalen Hämangiosarkomen wurden in der Universität der Pennsylvanischen Schule für Veterinäre Medizin in der Zeit von Juli 1952 bis September 1972 untersucht. Ein in Einzelheit gehender Krankenbefund von einem primären Hämangiosarkom des Humerus proximalis in einem zweiundhalbjährigen irischen Setter (dem die Eierstöcke entfernt waren) wurde, zusammen mit den hervorstechenden Merkmalen von zweiundzwanzig anderen Fällen, veröffentlicht. Die drei Rassen, am Meisten einbegriffen, waren Boxer, dänische Doggen und deutsche Schäferhunde. Ihr Alter belief sich von zwei bis elf Jahren mit einem Durchschnittsalter von sechs Jahren. Das männliche zum weibliche Verhältnis stand bei 1·6:1·0. Der Humerus proximalis und die Rippen waren die Knochen, welche am Meisten befallen waren. Die Röhrenknochen standen zu den Plattenknochen im Verhältnis von 1·0:1·33. In einigen Fällen war es schwierig oder unmöglich zu ermitteln ob das Hämangiosarkom in Knochen primär oder metastatisch war. Histologische Einstufung schien von wenig oder keinem prognostischem Wert.