Asthma is the top ten causes of morbidity and mortality in Indonesia. The correct use of inhalers is expected to control and reduce asthma attacks, but there are still many who do not understand the treatment of asthma in the use of proper inhalers. The role of the pharmacist in the application of pharmaceutical care has been shown to improve the outcome of clinical asthma patients in a pharmacy. This study aims to determine the effect of the application of pharmaceutical care on the use of inhalers and outcome of clinical asthma patients. This study used a comparative experimental method with a research design cohort-study prospectively before and after the intervention of 84 Asthma patients who met the inclusion criteria at the Pharmacy in June-August 2022. The data were then analyzed statistically using the wilcoxon. The results of research on the application of pharmaceutical care can increase the accuracy of using the MDI Inhaler, DPI Turbohaler and DPI Accuhaler, and improvement Outcome Clinically based on the APE value of 60.4 ± 26.2 to 91.9 ± 10.4 The results of the assessment of these two parameters from pretest and posttest showed that the changes that occurred were significant (P<0.05). Based on the results of the study it was concluded that the application of pharmaceutical care can increase the use of inhalation devices and increase Outcome Clinical Asthma patient in Pharmacy.