Synthesis of Bis(indolyl)methanes Catalyzed by Triethylborane. -(GARCIA MERINOS*, J. P.; LOPEZ RUIZ, H.; LOPEZ, Y.; ROJAS LIMA, S.; Lett. Org. Chem. 12 (2015) 5, 332-336, http://dx.doi.org/10.2174/1570178612666150220225335 ; Area Acad. Quim., Univ. Auton. Estado Hidalgo, 42184 Hidalgo, Mex.; Eng.) -A. Forchert 40-138

Triethylborane (TEB) was found to be a mild, efficient, and acid catalyst in electrophilic substitution reaction of indoles with aldehydes compounds to afford the corresponding bis(indolyl)methanes. Vibrindole A (5) and bis(indolyl)methanes derivatives 16 and 18 were synthesized using this methodology. Compound 16 is an intermediary in the synthesis of the natural bisindoles arsindoline B (2) and streptindole (6). The structure of vibrindole A (5) was unequivocally confirmed by a single crystal X-ray diffraction analysis.

No abstract