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Individual sites of ATP synthesis were studied in the Minute(2)z mutant of Drosophzla me2anogaster by supplying appropriate substrates to isolated mitochondria and determining the ratio of phosphorus esterifield to oxygen consumed at each locus. In this manner it was determined that the terminal locus of phosphorylation in the Minute is comparable to control, but the first two sites of ATP synthesis and possibly the substrate level phosphorylation are aberrant.The significance of these data and their relation to the Minute effect are discussed.

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