Background: Alzheimer's disease (AD) is a very common neurodegenerative disorder in individuals over 65 years of age, however, younger individuals can also be affected due to early brain damage. Introduction: The general symptoms of this disease include progressive loss of memory, changes in behavior, deterioration of thinking, and gradual loss of ability to perform daily activities. According to the World Health Organization, dementia has affected more than 50 million people worldwide, and it is estimated that there are 10 million new cases per year, of which 70% are due to AD. Methods: This paper reported a review of scientific articles available on the internet, which discussed in silico analyzes, such as molecular docking, molecular dynamics, and quantitative structure-activity relationship (QSAR) of different classes of natural products and their derivatives published from 2016 onwards. In addition, this work reports the potential of fermented papaya preparation against oxidative stress in AD. Results: With this research, it is expected that it will highlight the most recent studies about AD, the computational analysis methods used in proposing new bioactive and their possible molecular targets, and finally, the molecules or classes of natural products involved in each study. Conclusion: Thus, studies like this can orientate new works against neurodegenerative diseases, especially AD.

Perfil epidemiológico notificados dos casos de dengue no Estado da Paraíba no período de 2017 a 2019 Epidemiological profile of reported cases of dengue in the State of Paraíba in the period 2017 to 2019

Passion fruit, a well-known and commercialized fruit, is currently the target of studies that show its nutritional properties, namely its bark, rich in vitamins, minerals and dietary fiber, specifically soluble fibers, which bring benefits such as glycemic control and prevention of cardiovascular diseases. Due to the high rate of disposal of passion fruit peels, the use of the same in bakery products is an alternative to avoid its waste, taking advantage of the fruit in its entirety. The aim of this study was to prepare the biscuits with the flour from the shell of the passion fruit. This is an experimental, cross-sectional and quantitative study that was developed in the laboratories of Dietary Technique and Sensory Analysis of Food of the University Center of Science and Technology of Maranhão - UNIFACEMA, located in the city of Caxias - MA. The sensory analysis of the product was performed with 62 untrained evaluators, using the 9-point hedonic scale and 5-point purchase intention, by signing the TCLE. Microbiological analysis was performed to determine the microbiological conditions of the product. The results obtained show that of the three samples (A, B and C) developed, two (A and B) obtained acceptance by the evaluators. The results of the microbiological analysis indicated that the three samples are in accordance with current legislation. Therefore, the preparation of the biscuit proved to be a technological potential in the bakery market and as a healthy, sustainable and economic food option.

: Natural products are compounds isolated from plants that provide a variety of lead structures for the development of new drugs by the pharmaceutical industry. The interest in these substances increases because of their beneficial effects on human health. Alzheimer's disease (AD ) affects occur in about 80% of individuals aged 65 years. AD is the most common cause of dementia in elderly people, is characterized by progressive neurodegenerative alterations, as decrease of cholinergic impulse, increased toxic effects caused by reactive oxygen species and the inflammatory process that the amyloid plaque participates. In silico studies is relevant in the process of drug discovery; through technological advances in the areas of structural characterization of molecules, computational science and molecular biology have contributed to the planning of new drugs used against neurodegenerative diseases. Considering the social impairment caused by increased incidence of disease and that there is no chemotherapy treatment effective against the AD; several compounds are studied. In the researches for effective neuroprotectants as potential treatments for Alzheimer's disease, natural products that have been extensively studied in various AD models. This study aims to carry out a literature review with articles that address the In silico studies of natural products aimed at potential drugs against alzheimer's disease (AD) in the period from 2015 to 2021.

Severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) is a virus whose genetic material is positive single-stranded RNA, being responsible for coronavirus disease 2019 (COVID-19), an infection that compromises the lungs and consequently the respiratory capacity of the infected individual, according to the WHO in November 2021, 249,743,428 cases were confirmed, of which 5,047,652 individuals died due to complications resulting from the infection caused by SARS-COV-2. As the infection progresses, the individual may experience loss of smell and taste, as well as breathing difficulties, severe respiratory failure, multiple organ failure, and death. Due to this new epidemiological agent in March 2020 it was announced by the director general of the World Health Organization (WHO) a pandemic status, and with that, many research groups are looking for new therapeutic alternatives through synthetic and natural bioactives. This research is a literature review of some in silico studies involving natural products against COVID-19 inflammation published in 2020 and 2021. Work like this presents relevant information to the scientific community, boosting future research and encouraging the use of natural products for the search for new antivirals against COVID-19.