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Fused pyridine derivativesFused pyridine derivatives R 0450Fluorinated Dihydroquinolines as Potent n-NOS Inhibitors. -Ongoing research leads to the synthesis of novel n-NOS inhibitors such as (X). It is noteworthy that the side chain at the benzene ring is important for a better selectivity. The fluorine atom reduces the basicity of the amidine function which may be crucial for the passage through the blood brain barrier (no yields given). -(JAROCH*, S.; REHWINKEL, H.; HOELSCHER, P.; SUELZLE, D.; BURTON, G.; HILLMANN, M.; MCDONALD, F. M.; MIKLAUTZ, H.; Bioorg. Med.