Urinary excretion patterns of adult male Wistar rats exposed for 11 weeks to control (25°C) or to adverse conditions (5°C, 35°C), or simulated altitude (equivalent to 18,000 ft.) were determined using 24-hour fasting urine specimens collected weekly during the final 4 weeks. Relative to metabolic body weight (kg3/4), fasting water intake tended to vary directly with temperature, but urinary sodium, potassium, magnesium, calcium, phosphate, urea, valine and alanine tended to vary inversely with temperature. Creatinine, uric acid, histidine, glycine, serine, methionine, glutamic acid and aspartic acid excretion tended to vary nonlinearly with temperature. Altitude induced reductions in the majority of the urinary constituents.

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Ovarian follicular activity was significantly suppressed during treatment with levonorgestrel 100 micrograms/ethinylestradiol 20 micrograms. Similarly, endogenous ovarian steroid production was almost uniformly decreased. A 'dissociation' of ovarian and endometrial development was also seen during this therapy.

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