Background:The number of international travelers is estimated at 900 million per year and is projected to reach 1.6 billion per year in 2020. Travel medicine is devoted to the health of travelers who visit foreign countries. It is an interdisciplinary specialty concerned not only with prevention of communicable diseases during travel but also with the personal safety of travelers and the avoidance of environmental risks. This study aimed to review systematically the travel medicine practice to control transmision of communicable diseases. Subjects and Method: A systematic review was conducted by collecting several studies that examined travels medicine practice related to the spread of communicable disease. A total of 11 articles was selected for this study. The data were analyzed using narrative synthesis and a review of travel medicine practice. Results: Travel medicine practice was related to effective anticipation of communicable diseases including pre-travel health advice service, guideline, vaccination, and post-trip care. These practices could not be underestimated because virus and disease could easily spread when the tourists were not fit and exhausted during the trip. It was necessary for tourists to anticipate the spread of disease by knowing certain disease in the country and to have them vaccinated before traveling. Conclusion:Travel medicine practice has a significant impact on disease transmission anticipation among travellers/ tourists.