Background: Breast cancer is influenced by various risk factors, including age and obesity. Older women who are overweighted and obese have a higher risk of developing breast cancer. This study aims to find the correlation between age and body mass index (BMI) with histopathological features of breast cancer patients in RSUP Haji Adam Malik Medan.Methods: This research is an analytical study using a cross-sectional design with 103 samples obtained from medical record data by random sampling. The data obtained were then adjusted to the research criteria and grouped based on predetermined variables.Results: The majority of the age group was 41-50 years (36.9%), obesity BMI (40.8%), histopathological subtype of invasive carcinoma of no special type (NST) (85.4%), and grade II (46.6%). Kruskal-Wallis test result between histopathological subtypes and breast cancer grading based on age, respectively, obtained p=0.503, r=.325; (α>0.05), and p=0.207, r=0.393; (α>0.05), while based on BMI obtained p=0.017, r=0.021; (α<0.05), and p=0.018, r=0.018; (α<0.05). The OR value (95% CI) obtained on overweight-obese BMI with invasive carcinoma NST subtype was 7.63 (7.27–14.90) and other subtypes were 2.40 (1.14–13.75), and for grades II and III, they were respectively 3.57 (1.32–8.09) and 3.27 (1.17–9.91).Conclusions:  There was a correlation between BMI with histopathological subtypes and breast cancer grading, but the correlation tended to be weak. Whereas, with age, there was no correlation. BMI overweight-obese were more likely to have invasive carcinoma NST subtype and higher-grade of breast cancer.

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Di Indonesia angka kejadian fraktur cukup tinggi, dimana sekitar delapan juta orang mengalami fraktur femur yang diakibatkan oleh kecelakaan lalu lintas. Penelitian ini menggunakan metode deskriptif observasional dengan desain cross sectional. Sampel penelitian adalah seluruh populasi yang mengikuti kriteria inklusi dan ekslusi. Pemilihan sampel dilakukan dengan metode total sampling. Penelitian ini dilakukan dengan melihat data sekunder, yaitu rekam medis pasien fraktur femur akibat kecelakaan lalu lintas di RSUP H. Adam Malik pada tahun 2016-2018. Data kemudian dianalisis dengan program perangkat lunak statistik. Angka kejadian fraktur femur akibat kecelakaan lalu lintas di RSUP H. Adam Malik Medan tahun 2016-2018 didapatkan sebanyak 104 kasus. Prevalensi fraktur femur akibat kecelakaan lalu lintas terbanyak terjadi pada laki-laki sebanyak 81 kasus (77,9%), rentang usia 18-60 tahun yaitu sebanyak 84 kasus (80,8 %), tingkat pendidikan SMA sebanyak 51 kasus (49%), dengan fraktur femur tertutup sebanyak 70 kasus (67,3%) dan lokasi pada shaft femur sebanyak 70 kasus (67,3%). Kesimpulan: Karakteristik dari fraktur femur akibat kecelakaan lalu lintas di RSUP H. Adam Malik pada tahun 2016-2018 lebih banyak terjadi pada laki-laki, dengan kelompok usia paling banyak 18-60 tahun, tingkat pendidikan terakhir SMA, jenis fraktur terbanyak adalah fraktur tertutup, serta lokasi terbanyak adalah shaft femur.

Introduction: Spinal Meningiomas are most common in adult spinal tumors, account for 25-46% of tumors of spine with the highest incidence seen in thoracic region of middle-aged-woman.. Advance in radiological and surgical assistive devices have resulted earlier diagnosis. Surgical resection is the standard treatment and now associated with a good postoperative outcome. Case Report:A 47-year-old woman with 2 years history of numbness progressed below the umbilicus. Local pain on her back, walks in creeping way, urinary and fecal incontinence. MRI showing hypointense lesion on level T7, underwent surgical resection and histopathological examination revealed psammomatous meningioma (WHO Grade I). Patient discharged with improvement gait but some residual numbness and weakness on her right foot. Discussion: Meningiomas are primary tumors of spine, account for 25-46% of tumors of spine with the highest incidence seen in thoracic region of middle-aged-woman. Lead to symptoms only when they reach a considerable size to compress the spinal cord. Surgical resection is standard treatment and is now associated with a good postoperative outcome. Conclusion: Spinal Meningiomas with the highest incidence seen in thoracic region of middle-aged-woman. Present with pain, sensory loss, weakness and spinchter disturbance. MRI is recommended for the diagnosis. Surgical resection is standard treatment and associated with a good postoperative outcome.

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