Direct compression is the simplest and most efficient method of making tablets, but not all additives adopt this method. This research aims to analyze the ability of gelatinized cassava starch (Manihot utillissima) as an additive for the manufacture of tablets by direct compression using the acetosal active ingredient with a concentration of 100 mg. Furthermore, the cassava starch made from tubers (Manihot utillissima) is gelatinized by heating and then used as an additive in the manufacturing of acetosal tablets by direct compression. The results showed that the gelatinized cassava starch (Manihot utillissima) powder had good flow and compressibility properties and the acetosal acetosal tablets produced had good physical properties and solubility, therefore it was concluded that it is used as an additional ingredients in manufacturing acetosal tablets with direct compression method

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Whitening creams are very popular among women, both teenagers, and adults. They are tempted to use whitening cream products so that their facial skin looks bright and smooth. The whitening cream they use is not necessarily the right whitening cream and guarantees safety. This study aimed to compare the knowledge and attitudes between adolescent girls and adult women toward the use of harmful whitening creams. This research was conducted in February 2022 in Mattampae Village, Ponre District, Bone Regency. This study uses a descriptive comparative method with a quantitative approach. The sample in this study amounted to 55 respondents consisting of 2 groups, namely 29 adolescent female respondents and 26 adult female respondents who were obtained using a purposive sampling technique. The questionnaire distributed contained knowledge and attitudes, then the data was processed using Mann Whitney with a 95% confidence level using the SPSS program. The results of this study indicate that the knowledge of adolescent girls is in a good category (79.7%) and adult women in the category are quite good (73.1%). The attitude of adolescent girls' attitudes are quite good (74.9%) and adult women are also quite good (72%). From the results of the study, it can be concluded that there is no significant difference in knowledge and attitudes between adolescent girls and adult women in Mattampae Village, Ponre District, Bone Regency towards the use of harmful whitening creams with a p-value > 0.05.

The content of flavonoids, saponins and other compounds in white guava leaves (Syzygium malaccense(L.) Merr. & L.M. Perry) is quite high and has the potential to be used as an antibacterial. The purpose of this study was to analyze the antibacterial effectiveness of guava leaf extract against the growth of Escherichia Coli and Streptococcus Mutans. White guava leaves (Syzygium malaccense(L.) Merr. & L.M. Perry) were macerated with 96% ethanol. The test method used agar diffusion with 5 groups, namely negative control Na.CMC, concentrations of 2%, 4%, and 6%, and positive control Ciprofloxacin. The samples used were Escherichia Coli and Streptococcus Mutans. The inhibition obtained against Escherichia Coli at a concentration of 2% was 12.3 mm, the concentration of 4% was 14.3 mm, the concentration of 6% was 18.67 mm, while the positive control was 23 mm and the negative control was with Na.CMC no visible obstacle zone. While the results obtained by Streptococcus Mutans at a concentration of 2% was 8.67 mm, the concentration of 4% was 11.67 mm, the concentration of 6% was 16.3 mm, while the positive control was 31 mm and the negative control did not show any inhibition areas. so it can be concluded that Guava Leaf Extract (Syzygium malaccense(L.) Merr. & LM Perry) at concentrations of 2%, 4%, 6% had activity against the growth of Escherichia Coli and Streptococcus Mutans (p < 0.005) but its effectiveness was still below Ciprofloxacin.