This study aimed at measuring the quality of life among teachers in special education centers in Riyadh city in the light of two variables: Teacher’s gender and experience (less than 5 years, from 5-10 years, and more than 10 years). The study sample consisted of (201) teachers from both genders that were chosen in random sampling method. To achieve the objective of the study, the researchers developed a tool to measure the quality of life, which consisted of (36) items. The results of the study indicated that the quality of life in the study sample was average. The results also indicated that there are differences in the quality of life level according to the variable of the teacher’s gender which came in favor of male teachers, and that there are no differences in the quality of life level according to the experience variable. The study recommended encouraging teachers to share necessary experiences with their colleagues ate work and other individuals in surrounding community which shall contribute towards enhancing the quality of life, as well as trying to reduce the teachers' burdens through social support, and improving the level of school community to satisfy the teachers’ needs.