Nanoparticle Organic photovoltaic devices (NPs-OPVs) have received a great attention due to utilizing eco-friendly material to prepare active layer in OPV without any hazard on the environment. Herein, poly (3-hexylthiophene) (P3HT) is employed as a donor with a new and low cost fullerene ICxA to prepare NPs photoactive layer. The NPs photoactive layer is prepared by minemulation method generating core-shell structure. A DLS and STEM measurements are preformed to calculate the particle size (which is around 40 nm). Optical properties then demonstrated for P3HT: ICxA NPs compared with P3HT: PCBM NPs by using UV-vis measurements. The finding of this report reveals that the low cost and a new acceptor ICxA behaviour relativity agree with PCBM as commercial material in NPs structure.