Background: The fear of neuroscience by medical students is a global issue known as neurophobia which has been detected in medical schools from both developing and developed countries. It may contribute to the decreased number of neurologists that is already found to be low globally and augment the growing burden of neurological disorders. This study aimed to evaluate this issue among Sudanese medical students.Methods: A cross-sectional study was conducted on medical students from 8 medical schools using an online form questionnaire and responses were collected. Results: A total of 338 responses with 90.4% response rate were collected. Neurology was reported as the most difficult subject to learn (mean ± SD = 3.88 ± 0.90)(P< .01),the second least subject in drawing up differential diagnosis(3.32 ± 1.07) )(P =.000), the third least regarding confidence in clinical examination (3.23 ± 1.24)(P =.000),the third poorest quality of teaching (3.12 ± 1.26)(P =.000), and the third favorite subject as a career option (3.41 ± 1.4)(P > .004).Neuroanatomy was the biggest contributor to the difficulty of neurology (have a very large or large contribution by 51.5% of students) and More/Improved peer discussions were the most factor that could improve neurology teaching (mean ± SD = 3.47 ± 1.39). students perceive a career in neurology to be associated with good travel and research opportunities and poor job satisfaction and work/life balance. ability to make a significant difference in a patient’s life was the most factor encouraging students to chase a career in neurology (21.6%of students) and job satisfaction was the most discouraging factor (20.7%). On performing logistic regression, caring for a friend or relative suffering from neurological disease and increased confidence in knowing exactly what neurologists do were found to have a significant effect on increasing the possibility of pursuing a career in neurology (P =.01 and P< .005 respectively).Conclusion: Students’ perception of neurology is almost the same worldwide and didn’t change over decades in contrast to the growing burden of neurological diseases and population aging. So, a lot of work should be done globally to investigate and manage this issue.