No abstract

Some new tetrazole derivatives were prepared by the reaction between the prepared azomethine compounds I 6-I 10 with sodium azide in anhydrous tetrahydrofuran (THF) with a few drops of distilled water and under reflux conditions. Azomethine compounds were prepared by thermal condensation reactions of aromatic aldehydes with primary aromatic amines. The prepared compounds (tetrazole derivatives) were screened for their antibacterial activity (by disc diffusion method). Compound I 6 is the most active derivative that has recorded a significantly (p<0.01) stronger influence to inhibit the growth of Candida zeylanoides with an average zone of inhibition of 26.0 mm. Derivatives I 7 and I 9 showed the lowest zone of inhibition of 8.0 mm against Candida zeylanoides. This study may be helpful in designing more potential anticandidal agents for therapeutic use in the future.

This research includes synthesis of new heterocycles containing disubstituted Tetrazole derivatives. Imine compounds were synthesized by reaction of primary aromatic amines with various substituted benzaldehydes in the presence of glacial acetic acid as catalyst in absolute ethanol to obtain new imine compounds O 1-O 5. The novel five-membered heterocycles as Tetrazole derivatives O 6-O 10 were obtained from treatment of each new imine compounds with sodium azide compound. Newly synthesized compounds were identified via spectral methods (FT-IR, 1 H-NMR and 13 C-NMR) spectra and some physical properties. O 6 is the best derivative that has significantly (p<0.01) recorded a stronger influence to inhibit the growth of Candida guilliermondii at an average of the zone of inhibition 14.0 mm. While, O 9 derivative recorded the lowest zone of inhibition 7.3 mm toward the same clinical fungal pathogen. The present work may be helpful in designing more potential antibacterial and antifungal agents for therapeutic use in the future.