No abstract

In this article, we propose a strategy to show the combinability of multiple animal datasets in a parallel-line assay to estimate the relative potency. The following three assumptions are made in the linear fixed-effect modeling, and we examine if any of them result in nonconformance: The proposed procedure is demonstrated in an example analysis, and its properties are evaluated through a Monte Carlo simulation. The power of our proposed intrasubject parallelism criterion was shown to be high for designs of moderate size, but the demonstration of homogeneity via I 2 was rather conservative.

In this article, we propose an alternative criterion for evaluating parallelism in parallel-line assays at the subject level. Unlike another recently proposed criterion